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Doctor Octopus (Otto Octavius)

Played by Alfred Molina, Kathryn Hahn.

Marvel Cinematic Universe

• Spider-Man: No Way Home (2021), played by Alfred Molina

Spider-Man

• Spider-Man 2 (2004), played by Alfred Molina
• Spider-Man: Into the Spider-Verse (2018), played by Kathryn Hahn